||MT2012-11C: Second or Greater Allogeneic Hematopoietic Stem Cell
Transplant Using Reduced Intensity Conditioning (RIC)
||This is a treatment guideline to allow routine clinical data to be collected and maintained in OnCore and the University Of Minnesota Blood and Marrow Database as part of the historical database maintained by the department.
||This regimen, consisting of busulfan, fludarabine, and low dose total body irradiation (TBI), is designed to promote engraftment in patients with non-malignant diseases (NMD), and in rare cases with malignant diseases, who failed to achieve an acceptable level of donor-derived engraftment following a previous allogeneic HCT,including rare patients who may remain aplastic.
||This is a treatment guideline for a second or greater allogeneic hematopoietic stem cell transplant (HSCT) using a reduced intensity conditioning (RIC) in patients with non-malignant diseases and, in rare cases, with malignant diseases.
||Diagnosis of any disease for which a second or greater
hematopoietic stem cell transplant is needed due to insufficient
donor chimerism following hematopoietic recovery after previous
|Applicable Disease Sites
||Acute Lymphocytic Leukemia (ALL)
Acute myeloid leukemia (AML)
Brain and Nervous System
Central Nervous System
Chronic myeloid leukemia (CML)
Juvenile myelomonocytic leukemia (JMML)
Myelodysplastic syndromes (MDS)
Myeloid and Monocytic Leukemia
Myeloproliferative diseases (MPD)
||Blood and Marrow Transplant
Total Body irradiation (TBI)
||Masonic Cancer Center
||Must be no more than 55 years of age and have appropriate donor availability. Must be able to tolerate administration of total body irradiation. Women who are pregnant or nursing are not eligible. A signed informed consent and HIPAA authorization are required.